Journal article
Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
BM Brown, JJ Peiffer, K Taddei, JK Lui, SM Laws, VB Gupta, T Taddei, VK Ward, MA Rodrigues, S Burnham, SR Rainey-Smith, VL Villemagne, A Bush, KA Ellis, CL Masters, D Ames, SL MacAulay, C Szoeke, CC Rowe, RN Martins
Molecular Psychiatry | Published : 2013
DOI: 10.1038/mp.2012.107
Abstract
Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-β (Aβ) and Aβ brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Aβ and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) ε4 allele. Five-hundred and forty six cognitively intact participants (aged 60-95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were in..
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Funding Acknowledgements
BB is supported by a University Postgraduate Award from the University of Western Australia and a Freemason's Western Australia Student Award. Core funding for this study was provided by CSIRO, which was supplemented by 'in kind' contributions from study partners. This research is supported by the Science and Industry Endowment Fund. The AIBL investigators thank Richard Head of CSIRO for initiating and facilitating the AIBL collaboration. The study also received support from the National Health and Medical Research Council via the Dementia Collaborative Research Centres program. Pfizer International has contributed financial support to assist with analysis of blood samples and to further the AIBL research program. The McCusker Alzheimer's Research Foundation Inc. contributed financial and in kind support to AIBL. We thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD.